Navigation abilities and spatial anxiety in individuals with and without Developmental Coordination Disorder (DCD/Dyspraxia).

BACKGROUND: Navigation skills are essential for independent living as they allow us to explore our environment; find our way to new locations, refine pathways to familiar locations and retrace our route home. Alongside motor coordination difficulties, there is evidence that individuals with Developmental Coordination Disorder (DCD/Dyspraxia) experience spatial processing difficulties, which are known to negatively affect navigation abilities. However, although self-reports indicate that adults with DCD have difficulties with sense of direction and navigation, no known studies have measured navigation abilities and strategies in adults with DCD. Furthermore, given evidence that individuals with DCD report higher levels of anxiety, we will additionally investigate associations between anxiety and navigation in this group. AIMS: This study compares navigation abilities, navigation strategies and spatial anxiety in adults with and without DCD. METHODS: Participants include 226 Adults aged 18-55 years, across two groups 1) DCD (N = 138, 111 F:25 M; 2:Other) 2); Typically Developing (N = 88, 77 F: 11 M). In this cross-sectional study, participants completed a series of tasks on the online Qualtrics platform. This included the Adult Developmental Coordination Disorder Checklist, the State-Trait Anxiety Inventory, the Wayfinding Anxiety Measure, the Wayfinding Questionnaire, the Wayfinding Strategy Questionnaire, and a navigation task. RESULTS: Our analysis shows that 1) compared to those with typical development, individuals with DCD have similar navigation performance but lower navigation and orientation scores, and distance estimation scores. 2) Movement co-ordination difficulties were only a significant predictor of landmark recognition and egocentric path route knowledge, and played no role for other aspects of navigation performance. 3) For wayfinding strategy use the DCD group used orientation strategies significantly less often than those with typical development, however there was no group difference in the use of route strategies. 4) The DCD group had significantly higher spatial anxiety scores across navigation, manipulation and imagery spatial sub-domains, even after controlling for general anxiety. 5) Spatial navigation anxiety was a significant predictor of navigational skill for all three wayfinding measures (navigation & orientation, distance estimation and spatial anxiety). CONCLUSIONS: The findings establish benchmarks of navigational skills in DCD and highlight spatial anxiety and route strategies as factors that may inhibit navigation success and could help specify suitable intervention targets.

Direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation.

The subregions of the entorhinal cortex (EC) are conventionally thought to compute dichotomous representations for spatial processing, with the medial EC (MEC) providing a global spatial map and the lateral EC (LEC) encoding specific sensory details of experience. Yet, little is known about the specific types of information EC transmits downstream to the hippocampus. Here, we exploit in vivo sub-cellular imaging to record from EC axons in CA1 while mice perform navigational tasks in virtual reality (VR). We uncover distinct yet overlapping representations of task, location, and context in both MEC and LEC axons. MEC transmitted highly location- and context-specific codes; LEC inputs were biased by ongoing navigational goals. However, during tasks with reliable reward locations, the animals' position could be accurately decoded from either subregion. Our results revise the prevailing dogma about EC information processing, revealing novel ways spatial and non-spatial information is routed and combined upstream of the hippocampus.

Congenital lack and extraordinary ability in object and spatial imagery: An investigation on sub-types of aphantasia and hyperphantasia.

Studies that have shown a distinction between object and spatial imagery suggest more than one type of aphantasia and hyperphantasia, yet this has not been systematically investigated in studies on imagery ability extremes. Also, if the involuntary imagery is preserved in aphantasia and how this condition affects other skills is not fully clear. We collected data on spatial and object imagery, retrospective, and prospective memory, face recognition, and sense of direction (SOD), suggesting a distinction between two subtypes of aphantasia/hyperphantasia. Spatial aphantasia is associated with difficulties in visuo-spatial mental imagery and SOD. Instead, in object aphantasia there are difficulties in imaging single items and events - with no mental visualization of objects, out-of-focus, and black-and-white mental images more frequent than expected - in SOD and face recognition. Furthermore, associative involuntary imagery can be spared in aphantasia. The opposite pattern of performance was found in spatial and object hyperphantasia.

Complementary encoding of spatial information in hippocampal astrocytes.

Calcium dynamics into astrocytes influence the activity of nearby neuronal structures. However, because previous reports show that astrocytic calcium signals largely mirror neighboring neuronal activity, current information coding models neglect astrocytes. Using simultaneous two-photon calcium imaging of astrocytes and neurons in the hippocampus of mice navigating a virtual environment, we demonstrate that astrocytic calcium signals encode (i.e., statistically reflect) spatial information that could not be explained by visual cue information. Calcium events carrying spatial information occurred in topographically organized astrocytic subregions. Importantly, astrocytes encoded spatial information that was complementary and synergistic to that carried by neurons, improving spatial position decoding when astrocytic signals were considered alongside neuronal ones. These results suggest that the complementary place dependence of localized astrocytic calcium signals may regulate clusters of nearby synapses, enabling dynamic, context-dependent variations in population coding within brain circuits.

Spatial anxiety and spatial ability: Mediators of gender differences in math anxiety.

Females tend to be more anxious than males while engaging in mathematics, which has been linked to lower math performance and higher math avoidance. A possible repercussion of this gender difference is the underrepresentation of females in STEM fields (science, technology, engineering, and math), as math competencies are an essential part of succeeding in such fields. A related, but distinct, area of research suggests that males tend to outperform females in tasks that require spatial processing (i.e., the ability to mentally visualize, rotate, and transform spatial and visual information). Interestingly, factors from the spatial processing domain (spatial ability and spatial anxiety) are important in explaining gender differences in math anxiety. Here, we examined three types of spatial anxiety and ability (imagery, navigation, and manipulation), as well as math ability, as mediators of gender differences in math anxiety. Undergraduate students (125 male; 286 female) completed assessments of their general level of anxiety, their math anxiety, and their spatial anxiety. They also completed a series of tasks measuring their mathematical skill, their spatial skills, and basic demographics. Results suggest that manipulation anxiety and ability, navigation anxiety, and math ability explained the gender difference in math anxiety, but manipulation anxiety was the strongest mediator of this relation. Conversely, all other measures did not explain the gender difference in math anxiety. These findings help us better understand the gender difference in mathematics, and this is important in reducing the gender gap in STEM fields. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

A model of head direction and landmark coding in complex environments.

Environmental information is required to stabilize estimates of head direction (HD) based on angular path integration. However, it is unclear how this happens in real-world (visually complex) environments. We present a computational model of how visual feedback can stabilize HD information in environments that contain multiple cues of varying stability and directional specificity. We show how combinations of feature-specific visual inputs can generate a stable unimodal landmark bearing signal, even in the presence of multiple cues and ambiguous directional specificity. This signal is associated with the retrosplenial HD signal (inherited from thalamic HD cells) and conveys feedback to the subcortical HD circuitry. The model predicts neurons with a unimodal encoding of the egocentric orientation of the array of landmarks, rather than any one particular landmark. The relationship between these abstract landmark bearing neurons and head direction cells is reminiscent of the relationship between place cells and grid cells. Their unimodal encoding is formed from visual inputs via a modified version of Oja's Subspace Algorithm. The rule allows the landmark bearing signal to disconnect from directionally unstable or ephemeral cues, incorporate newly added stable cues, support orientation across many different environments (high memory capacity), and is consistent with recent empirical findings on bidirectional HD firing reported in the retrosplenial cortex. Our account of visual feedback for HD stabilization provides a novel perspective on neural mechanisms of spatial navigation within richer sensory environments, and makes experimentally testable predictions.

The hypothalamus coordinates diverse escape strategies from threat.

The neural circuits orchestrating complex behavioral response strategies to threat are not understood. In this issue of Neuron, Wang et al. (2021) establish the hypothalamic dorsal premammillary nucleus as a critical node that communicates with thalamic and midbrain regions to coordinate diverse escape strategies.

Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats.

Naturalistic escape requires versatile context-specific flight with rapid evaluation of local geometry to identify and use efficient escape routes. It is unknown how spatial navigation and escape circuits are recruited to produce context-specific flight. Using mice, we show that activity in cholecystokinin-expressing hypothalamic dorsal premammillary nucleus (PMd-cck) cells is sufficient and necessary for context-specific escape that adapts to each environment's layout. In contrast, numerous other nuclei implicated in flight only induced stereotyped panic-related escape. We reasoned the dorsal premammillary nucleus (PMd) can induce context-specific escape because it projects to escape and spatial navigation nuclei. Indeed, activity in PMd-cck projections to thalamic spatial navigation circuits is necessary for context-specific escape induced by moderate threats but not panic-related stereotyped escape caused by perceived asphyxiation. Conversely, the PMd projection to the escape-inducing dorsal periaqueductal gray projection is necessary for all tested escapes. Thus, PMd-cck cells control versatile flight, engaging spatial navigation and escape circuits.

Neurons including hippocampal spatial view cells, and navigation in primates including humans.

A new theory is proposed of mechanisms of navigation in primates including humans in which spatial view cells found in the primate hippocampus and parahippocampal gyrus are used to guide the individual from landmark to landmark. The navigation involves approach to each landmark in turn (taxis), using spatial view cells to identify the next landmark in the sequence, and does not require a topological map. Two other cell types found in primates, whole body motion cells, and head direction cells, can be utilized in the spatial view cell navigational mechanism, but are not essential. If the landmarks become obscured, then the spatial view representations can be updated by self-motion (idiothetic) path integration using spatial coordinate transform mechanisms in the primate dorsal visual system to transform from egocentric to allocentric spatial view coordinates. A continuous attractor network or time cells or working memory is used in this approach to navigation to encode and recall the spatial view sequences involved. I also propose how navigation can be performed using a further type of neuron found in primates, allocentric-bearing-to-a-landmark neurons, in which changes of direction are made when a landmark reaches a particular allocentric bearing. This is useful if a landmark cannot be approached. The theories are made explicit in models of navigation, which are then illustrated by computer simulations. These types of navigation are contrasted with triangulation, which requires a topological map. It is proposed that the first strategy utilizing spatial view cells is used frequently in humans, and is relatively simple because primates have spatial view neurons that respond allocentrically to locations in spatial scenes. An advantage of this approach to navigation is that hippocampal spatial view neurons are also useful for episodic memory, and for imagery.

Supporting route learning in older adults: the role of imagery strategy.

OBJECTIVES: Route learning is an everyday spatial ability important to individuals' independent living, and is known to decline with age. This study aimed to investigate the benefit of using an imagery strategy to support route learning in young and older adults. METHODS: Forty young adults and 40 older adults learned a path from a video. Twenty of each age group were taught to use an imagery strategy (strategy groups [SGs]), while the others received no specific instructions (control groups [CGs]). Then participants were asked to recall the order and location of landmarks they had seen along the path (landmark ordering and locating tasks). RESULTS: Young adults recalled the order and location of landmarks better than older adults, and the SGs outperformed the CGs regardless of age. The Age group x Learning group interaction was only significant for the landmark locating task, with the young CG performing better than the older CG, while the older SG proved as good at recalling landmark locations as the young SG. Further, it was only among the older adults that the SG outperformed the CG. CONCLUSION: These findings newly suggest that using imagery helps to sustain older adults' route learning ability, especially in spatial recall tasks demanding the active manipulation of spatial information learnt, such as locating landmarks previously encountered while navigating a path. These results are discussed within the aging and spatial cognition frameworks.

On the relationship between trait autobiographical episodic memory and spatial navigation.

Influential research has focused on identifying the common neural and behavioural substrates underlying episodic memory (the re-experiencing of specific details from past experiences) and spatial cognition, with some theories proposing that these are supported by the same mechanisms. However, the similarities and differences between these two forms of memory in humans require further specification. We used an individual-differences approach based on self-reported survey data collected in a large online study (n = 7,487), focusing on autobiographical episodic memory and spatial navigation and their relationship to object and spatial imagery abilities. Multivariate analyses replicated prior findings that autobiographical episodic memory abilities dissociated from spatial navigational abilities. Considering imagery, episodic autobiographical memory overlapped with imagery of objects, whereas spatial navigation overlapped with a tendency to focus on spatial schematics and manipulation. These results suggest that trait episodic autobiographical memory and spatial navigation correspond to distinct mental processes.

Physician Wellness in Orthopedic Surgery: Challenges and Solutions.

The growing epidemic of physician burnout suggests that a change is needed. Physician wellness is an ever-growing consideration, especially in orthopedic surgery, where the challenges to wellness are significant. This review provides many common sense wellness principles and solutions in four main components of wellness (physical, mental, emotional, and spiritual) interwoven with current research on the topic. Although directed to orthopedic surgeons, this guide can be applied to all physicians, because they are based on common human principles of wellness. Wellness is not created overnight, so wellness practices that increase the likelihood of experiencing wellness are encouraged.

An Important Step toward Understanding the Role of Body-based Cues on Human Spatial Memory for Large-Scale Environments.

Moving our body through space is fundamental to human navigation; however, technical and physical limitations have hindered our ability to study the role of these body-based cues experimentally. We recently designed an experiment using novel immersive virtual-reality technology, which allowed us to tightly control the availability of body-based cues to determine how these cues influence human spatial memory [Huffman, D. J., & Ekstrom, A. D. A modality-independent network underlies the retrieval of large-scale spatial environments in the human brain. Neuron, 104, 611-622, 2019]. Our analysis of behavior and fMRI data revealed a similar pattern of results across a range of body-based cues conditions, thus suggesting that participants likely relied primarily on vision to form and retrieve abstract, holistic representations of the large-scale environments in our experiment. We ended our paper by discussing a number of caveats and future directions for research on the role of body-based cues in human spatial memory. Here, we reiterate and expand on this discussion, and we use a commentary in this issue by A. Steel, C. E. Robertson, and J. S. Taube (Current promises and limitations of combined virtual reality and functional magnetic resonance imaging research in humans: A commentary on Huffman and Ekstrom (2019). Journal of Cognitive Neuroscience, 2020) as a helpful discussion point regarding some of the questions that we think will be the most interesting in the coming years. We highlight the exciting possibility of taking a more naturalistic approach to study the behavior, cognition, and neuroscience of navigation. Moreover, we share the hope that researchers who study navigation in humans and nonhuman animals will synergize to provide more rapid advancements in our understanding of cognition and the brain.

Neuronal vector coding in spatial cognition.

Several types of neurons involved in spatial navigation and memory encode the distance and direction (that is, the vector) between an agent and items in its environment. Such vectorial information provides a powerful basis for spatial cognition by representing the geometric relationships between the self and the external world. Here, we review the explicit encoding of vectorial information by neurons in and around the hippocampal formation, far from the sensory periphery. The parahippocampal, retrosplenial and parietal cortices, as well as the hippocampal formation and striatum, provide a plethora of examples of vector coding at the single neuron level. We provide a functional taxonomy of cells with vectorial receptive fields as reported in experiments and proposed in theoretical work. The responses of these neurons may provide the fundamental neural basis for the (bottom-up) representation of environmental layout and (top-down) memory-guided generation of visuospatial imagery and navigational planning.

Mental rotation ability and spontaneous brain activity: a magnetoencephalography study.

We performed experiments using magnetoencephalography to clarify the relationship between three-dimensional visuospatial abilities and spontaneous visual thinking characteristics. Subjects were divided into two groups based on the rate of correct answers to mental rotation tasks: those with good performances (Group G) and those with bad performances (Group B). We found the followings: (1) in the mental rotation tasks, the 25-35 Hz lower γ band activities in the superior parietal lobule/intraparietal sulcus regions and in the occipitotemporal region were significantly larger in Group G than in Group B and (2) in the spontaneous mental imagery tasks, the 20-Hz band activity in the left premotor cortex and the 35-Hz band activity in the supplementary motor area were significantly larger in Group G.

Enhanced spatial navigation skills in sequence-space synesthetes.

Individuals with sequence-space synesthesia (SSS) perceive sequences like months, days and numbers in certain spatial arrangements. Several cognitive benefits have been associated with SSS, such as enhanced mental rotation, more vivid visual imagery and an advantage in spatial processing. The current study aimed to further investigate these cognitive benefits, focusing on spatial navigation skills, to explore if their enhanced sensitivity to spatial relations is reflected in enhanced navigational performance. Synesthetes were distinguished from controls by means of a questionnaire, a consistency test and drawings. A virtual Morris Water Maze (MWM) task with two allocentric and two egocentric navigation conditions was used to assess spatial navigation abilities. For the allocentric tasks, participants had to use object cues to find a hidden platform and for the egocentric tasks, they had to use their own position as a reference. Results showed that synesthetes performed significantly better compared to controls on the allocentric and egocentric tasks that reflected real life situations more accurately. However, this significant result was only found for the time taken to find the platform and not for the length of the path that was taken. In exploratory analyses, no significant relations were found between task performance and the specific features of the manifestation of each individual's synesthesia. Our hypothesis that synesthetes with the ability to mentally rotate their spatial arrangements would perform better on the allocentric task was not confirmed. Results add to the growing body of literature concerning the cognitive benefits of SSS and are consistent with the possibility that enhanced spatial navigation skills emerge from generally enhanced visuospatial abilities in SSS.

[Poststroke cognitive impairment and the possibility of its nonpharmacological treatment with vestibular stimulation based on biological feedback to supporting reaction]. / Kognitivnye narusheniia posle insul'ta i vozmozhnosti ikh nefarmakologicheskoi korrektsii s primeneniem vestibuliarnoi stimuliatsii na osnove biologicheskoi obratnoi sviazi po opornoi reaktsii.

Cognitive impairment is common in poststroke patients. Today in rehabilitation programs the specialists use the vestibular stimulation including biological feedback to supporting reaction for treatment poststroke cognitive impairment. These studies show the relationship of vestibular function with memory, attention, spatial orientation, navigation, mental representation of three-dimensional space and other cognitive functions. It makes possible to build rehabilitation programs for patients with stroke.

A mirror in the sky: assessment of an augmented reality method for depicting navigational information.

We investigated the efficacy of a novel augmented reality (AR) navigation display called Mirror in the Sky (MitS). AR displays can reduce the distance between virtual imagery content and the user's view of the environment but may have limited benefit for depicting map-based survey information. MitS presents a simulated mirror in the upper visual field, which reflects the topographic layout of the terrain in front of the user. In our experiment, 28 participants used MitS and a track-up Map in virtual reality to perform a route confirmation task, which required participants to decide whether a route could be successfully navigated. A post-trial threat location recall task examined spatial awareness. On that task, accuracy, duration, and subjective workload measures favoured the Map. However, participants with virtual reality experience made more accurate route confirmation decisions with MitS than the Map. Practitioner summary: We compared an augmented reality display called Mirror in the Sky (MitS) to a conventional electronic map for route confirmation and threat location tasks. Although the electronic map showed advantages over MitS on some measures, users with some VR experience performed route confirmation more accurately with MitS than a map.

Association between prism adaptation and auditory cues on spatial navigation in individuals with unilateral neglect.

BACKGROUND: Unilateral neglect is common among right-hemispheric stroke individuals and also concerns the auditory modality. Prism adaptation can improve auditory extinction during a dichotic listening task, but its effect during an ecological task has not been studied. OBJECTIVE: The main objective was to evaluate whether lateralized cueing before and after prism adaptation improved virtual spatial navigation of stroke individuals with visual and auditory unilateral neglect. Secondary objectives were to assess spatial memory and obtain a better understanding of the mechanism of the cueing treatment by using an eye-tracker. METHODS: We included 22 stroke individuals with left visual and auditory neglect, 14 individuals without neglect, and 12 healthy controls. After a familiarization task, participants underwent 3 evaluation sessions. Participants were first passively shown a path that they had then to actively reproduce by using a joystick. A path with lateralized beeping sounds indicating direction and a path without any sounds were followed in a randomized order. After prism adaptation, the participants followed a third path with lateralized beeping sounds. The time of navigation and number of trajectory mistakes were recorded. After navigation, spatial memory was assessed. Additionally, an eye-tracker was used during the navigation period. RESULTS: The navigational performance of participants with neglect was significantly better with than without auditory cues, especially after prism adaptation. With auditory cues, participants without neglect reached the navigational performance of healthy controls. The spatial memory of individuals with neglect was significantly lower with auditory cues. Eye-tracking analyses showed that participants with neglect made more saccades and looked longer at the right-square angles in the absence of auditory cues. CONCLUSIONS: This study demonstrates the positive effect of auditory cues in virtual spatial navigation of individuals with visual and auditory neglect and the potentiation of the help of cues after prism adaptation.

Changes in brain activation related to visuo-spatial memory after real-time fMRI neurofeedback training in healthy elderly and Alzheimer's disease.

Cognitive decline is a symptom of healthy ageing and Alzheimer's disease. We examined the effect of real-time fMRI based neurofeedback training on visuo-spatial memory and its associated neuronal response. Twelve healthy subjects and nine patients of prodromal Alzheimer's disease were included. The examination spanned five days (T1-T5): T1 contained a neuropsychological pre-test, the encoding of an itinerary and a fMRI-based task related that itinerary. T2-T4 hosted the real-time fMRI neurofeedback training of the parahippocampal gyrus and on T5 a post-test session including encoding of another itinerary and a subsequent fMRI-based task were done. Scores from neuropsychological tests, brain activation and task performance during the fMRI-paradigm were compared between pre and post-test as well as between healthy controls and patients. Behavioural performance in the fMRI-task remained unchanged, while cognitive testing showed improvements in visuo-spatial memory performance. Both groups displayed task-relevant brain activation, which decreased in the right precentral gyrus and left occipital lobe from pre to post-test in controls, but increased in the right occipital lobe, middle frontal gyrus and left frontal lobe in the patient group. While results suggest that the training has affected brain activation differently between controls and patients, there are no pointers towards a behavioural manifestation of these changes. Future research is required on the effects that can be induced using real-time fMRI based neurofeedback training and the required training duration to elicit broad and lasting effects.